Skip to product information
Introducing Age Lift 5+
Advanced PDRN helps support collagen and skin regeneration
Shop Now

The Complete Age-Defying Routine — PDRN Skincare Set

The Complete Age-Defying Routine — PDRN Skincare Set

Save $31.00
Regular price $72.00
$72.00 Regular price $103.00 Sale price
Clinically Tested · Dermatologist-Grade PDRN Technology is applied at checkout!
One routine, three steps, real results. Our Age Lift 5+ PDRN Serum, Skin Clear+ Serum, and Hydrating Toner work together to visibly lift, smooth, and brighten skin — clinically shown to reduce nasolabial fold appearance by 44% in just 2 weeks.
44% Less Fine Lines
21% Less Pigmentation
Results in 2 Weeks
3 Full-Size Products
Select Bundle:
Free shipping on orders $49+
30 Day Free Trial
Satisfaction guarantee
30-Day Money-Back Guarantee
That's how confident we are in your results. But if you're not thrilled, send it back and we'll refund your purchase.
Learn More
  • Amazon
  • American Express
  • Apple Pay
  • Diners Club
  • Discover
  • Google Pay
  • Mastercard
  • PayPal
  • Shop Pay
  • Visa
PDRN SERUM (AGE LIFT 5+) INGREDIENTS

Key Ingredients:

PDRN (Sodium DNA) — regenerative gold-standard ingredient extracted from chum salmon milt, closely resembling human DNA

Niacinamide (Vitamin B3) — brightens & smooths fine lines

Peptides — boost collagen for firmer skin

Hyaluronic Acid (Sodium Hyaluronate) — deep hydration & plumping

Antioxidant Oils (Grape Seed, Macadamia, Meadowfoam) — nourish & protect

Full ingredient list:

Water, Glycerin, Macadamia Ternifolia Seed Oil, Limnanthes Alba (Meadowfoam) Seed Oil, Niacinamide, PEG-60 Hydrogenated Castor Oil, PEG-40 Stearate, Panthenol, PVP, Vitis Vinifera (Grape) Seed Oil, Cetearyl Olivate, Sorbitan Olivate, Tocopheryl Acetate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Butylene Glycol, Zingiber Officinale (Ginger) Root Extract, Schisandra Chinensis Fruit Extract, Camellia Sinensis Leaf Extract, Allantoin, Fragrance, Dipotassium Glycyrrhizate, Adenosine, 1,2-Hexanediol, Hydrogenated Polyisobutene, Anemarrhena Asphodeloides Root Extract, Sodium DNA, Caprylyl Glycol, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Sodium Hyaluronate, Asiaticoside.

SKIN CLEAR+ SERUM INGREDIENTS

Key Ingredients:

Centella Asiatica — calming support

Licorice Root — brightening & soothing

Peony Root — skin balance

Scutellaria Root — antioxidant support

Terminalia Chebula — skin clarity

Rosa Centifolia — soothing care

Houttuynia Cordata — calming support

Peptides — skin repair support

Hyaluronic Acid — lightweight hydration

Full ingredient list:

Water, Glycerin, 1,2-Hexanediol, Terminalia Chebula Fruit Extract, Phellodendron Amurense Bark Extract, Poterium Officinale Root Extract, Rosa Centifolia Flower Water, Glycyrrhiza Glabra (Licorice) Root Extract, Paeonia Suffruticosa Root Extract, Scutellaria Baicalensis Root Extract, Centella Asiatica Extract, Sodium Hyaluronate, PEG-60 Hydrogenated Castor Oil, Butylene Glycol, Resveratrol, Salvia Plebeia Extract, Moringa Oleifera Seed Extract, Caprylyl Glycol, Houttuynia Cordata Extract, PVP, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Allantoin, Dipotassium Glycyrrhizate, Eucalyptus Globulus Leaf Oil.

HYDRATING FACE TONER INGREDIENTS

Key Ingredients:

Ceramide NP — helps strengthen the skin barrier

Peptides — support smoother, healthier-looking skin

Hyaluronic Acid — helps retain moisture & improve softness

Rose Water — calms & refreshes skin; Butterfly Pea Flower — antioxidant support & radiance

Centella Complex — soothes & supports skin recovery

Full ingredient list:

Water, Glycerin, Methylpropanediol, 1,2-Hexanediol, Clitoria Ternatea (Butterfly Pea Flower) Flower Extract, Rosa Centifolia Flower Water, Butylene Glycol, Caprylic/Capric Triglyceride, Isoamyl Laurate, Hydrogenated Lecithin, Phospholipids, Caprylyl Glycol, Ceramide NP, Asiaticoside, Madecassoside, Resveratrol, Moringa Oleifera Seed Extract, Houttuynia Cordata Extract, Salvia Plebeia Extract, Sodium Hyaluronate, PEG-60 Hydrogenated Castor Oil, Allantoin, Dipotassium Glycyrrhizate, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Fragrance.

WHAT MAKES THIS ROUTINE DIFFERENT

This Complete Age-Defying Routine brings together three purpose-built formulas instead of asking you to guess which single product your skin needs. Age Lift 5+ Serum, powered by PDRN (Salmon DNA Complex), targets the 5 visible signs of aging — firmness, smoothness, elasticity, brightness, and renewal. Skin Clear+ Serum calms breakouts, redness, and irritation without the harsh drying effects of typical acne treatments. Hydrating Face Toner preps and hydrates skin immediately after cleansing, strengthening the barrier so the two serums that follow can absorb and perform better.

Instead of three unrelated products, this is a complete system — hydrate, treat, and repair — built on Gloves In A Bottle's 30-year barrier-care philosophy, now applied to the face.

HOW QUICKLY CAN I EXPECT RESULTS


Across all three products, the pattern is consistent: 1–2 weeks for improved hydration, softness, and calmer, more radiant-looking skin. 4–8 weeks of consistent daily use for the deeper, visible changes — firmer, smoother texture and reduced fine lines from Age Lift 5+; improved pore appearance, reduced redness, and clarity from Skin Clear+; and strengthened barrier resilience from the toner. Skin renewal is a gradual process, and results continue to improve with continued use of the full routine.

HOW TO USE

Apply in this order, morning and evening:

Cleanse → Hydrating Face Toner → Skin Clear+ Serum → Age Lift 5+ Serum → Moisturizer → SPF (daytime)

1. After cleansing, spray the Hydrating Face Toner evenly onto face and neck.

2. Apply a few drops of Skin Clear+ Serum, pressing gently into skin until absorbed.

3. Follow with 2–4 drops of Age Lift 5+ Serum, pressed into face and neck.

4. Finish with moisturizer, and SPF during the day.

The toner can also be used throughout the day as a refreshing mist whenever skin needs a boost

IS THIS SAFE?

Yes. All three products in this routine are formulated for facial use and designed to be gentle enough for all skin types, including sensitive and acne-prone skin. Each formula is lightweight, non-comedogenic, and built to support — not strip — the skin barrier. None contain harsh drying agents; the routine is designed to hydrate and calm while still delivering active, clinically backed results.

For external use only. Avoid contact with eyes. As with any skincare routine, patch testing before full use is recommended, especially for sensitive skin.

At Gloves In A Bottle, we have always focused on supporting the skin’s natural barrier and helping it stay healthy and resilient. As we grew, many of our customers asked us to bring that same philosophy to facial skincare, which led to the development of Age Lift 5+ Serum. We carefully selected advanced ingredients, including PDRN, a next-generation skin renewal complex known to support elasticity, smoothness, and visible skin rejuvenation. Our goal was to create a formula that helps improve the appearance of aging skin while remaining gentle and supportive of the skin’s natural balance. I’m proud to introduce Age Lift 5+ Serum as part of our continued dedication to effective, skin-supportive care.
Katya Sobol - Brand Director, Gloves In A Bottle
View full details
frequently asked questions
How do I use all three products together?
Apply in this order: Cleanse → Hydrating Face Toner → Skin Clear+ Serum → Age Lift 5+ Serum → Moisturizer → SPF (daytime). The toner preps and hydrates skin so the serums absorb better; layering SkinClear+ before Age Lift 5+ lets you target breakouts and calm irritation first, then follow with the anti-aging treatment.
How quickly will I see results from the full routine?
Most users notice improved hydration, softness, and calmer skin within 1–2 weeks. Visible improvements in firmness, elasticity, fine lines, pigmentation, and pore appearance typically develop over 4–8 weeks with consistent daily use of the full set.
Is this routine suitable for sensitive or acne-prone skin?
Yes. All three products are formulated to be gentle and non-comedogenic and are safe for sensitive and acne-prone skin. Skin Clear+ in particular is designed to calm breakouts and irritation without the dryness common in harsher acne treatments.
Can I use all three products every day?
Yes. The full routine is designed for daily morning and evening use. The toner can also be reapplied throughout the day to refresh and hydrate as needed.
Is this bundle only for aging skin, or can I use it preventatively?
Both. Age Lift 5+ Serum supports collagen and elasticity even before visible signs of aging appear, while Skin Clear+ and the toner support ongoing skin barrier health at any age — so the full routine works whether you're addressing existing concerns or maintaining healthy skin.
Why buy the bundle instead of the products separately?
Beyond the savings (up to 60% off buying individually), the three products are formulated to work together — the toner preps skin for better serum absorption, and layering Skin Clear+ with Age Lift 5+ lets you target breakouts and aging in one routine instead of guessing which single product to start with.
What if the routine doesn't work for my skin?
Every Gloves In A Bottle purchase is backed by our 30-Day Money-Back Guarantee — if you're not satisfied, send it back for a full refund.
  • 5 stars: 44 (73%)
  • 4 stars: 16 (27%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
S
Sustainable Vic
Smooth, non-greasy formula featuring clean ingredients

The media could not be loaded.









The Skin Clear+ Serum by skin barrier brand Gloves in a Bottle is made of some real, potent ingredients. Hyaluronic acid and peptide ingredients are the stars of the show in this one. The serum can be applied on your hands or directly to the face, leaving behind a smooth, non-greasy feel, absorbing the clean ingredients quickly into your skin. Once it's fully absorbed, it leaves my face feeling silky smooth. Using this serum for a full week, I notice the benefits right away, such as even skin tone, acne-free and blemish-free skin. I'm happy to make this a part of my daily skin routine.The packaging for this serum came in a perfectly fitted cardboard box x2. The boxes themselves, however, came shrink-wrapped in single-use, non-recyclable plastic, which it could really do without.Otherwise, Gloves in a Bottle really released a fine, thoughtful product to add to their skin barrier lineup and I look forward to more skin products from them. Available at an excellent value.

S
Sustainable Vic
Age defying miracle product!

The media could not be loaded.









The PDRN Age Lift 5+ Serum by skin barrier brand Gloves in a Bottle is made of some real far out formula. PDRN (which i learned is salmon DNA), niacinamide, peptides, and grapeseed oil lead the ingredient lineup. The serum can be applied on your hands or directly to the face, leaving behind a smooth, non-greasy feel, absorbing the clean ingredients quickly into your skin. And largely odorless. Once it's fully absorbed, it leaves my face feeling silky smooth. Using this serum for a full two weeks now, I notice the benefits right away, such as smoother, less wrinkly skin, increased suppleness, more hydration and elasticity... A miracle product! I'm happy to make this a part of my nightly skin routine.The packaging for this serum came in a perfectly fitted cardboard box x2. The boxes themselves, however, came shrink-wrapped in single-use, non-recyclable plastic, which it could really do without.Otherwise, Gloves in a Bottle really released a fine, thoughtful product to add to their skin barrier lineup and I look forward to more skin products from them. Available at an excellent value.

S
SM
Lightweight serum that feels great on my skin

I’ve been enjoying this serum as part of my daily skincare routine. The gel texture is lightweight, absorbs quickly, and doesn’t leave my skin feeling sticky or greasy.It layers well with my other skincare products and provides a nice boost of hydration while leaving my skin feeling smooth and comfortable. I also like that it feels gentle and hasn’t caused any irritation.With continued use, my skin has been looking more balanced, and I like how easy it is to incorporate into both my morning and evening routines.

S
Sustainable Vic
Leaves my face feeling silky smooth

The media could not be loaded.









This toning spray by skin barrier brand Gloves in a Bottle is made of some real, potent ingredients. Hyaluronic avoid, ceramides, and peptides are ingredients often sought in facial toners, and this product conveniently includes all three, and then some. The spray is applied directly to the face, leaving behind a gentle, watery mist, absorbing the clean ingredients quickly into your skin. Once it's fully absorbed, it leaves my face feeling silky smooth. Using this toner for a full week, I notice the benefits right away and will gladly make this a part of my skin routine.The packaging for this toner came in a perfectly fitted cardboard box. The box itself, however, came shrink-wrapped in single-use, non-recyclable plastic, which it could really do without.Otherwise, Gloves in a Bottle really released a fine, thoughtful product to add to their skin barrier lineup and I look forward to more skin products from them. Available at an excellent value.

B
Bob
I love it for my skin!

This 2-in-1 toner and mist delivers deep hydration and skin barrier support through a blend of hyaluronic acid, ceramide NP, and peptides. Ceramide NP works to strengthen the skin's protective barrier, while peptides support smoother, healthier-looking skin over time. Calming rose water and antioxidant-rich butterfly pea flower soothe redness and enhance radiance, and a centella asiatica complex further aids skin recovery. Alcohol-free and gentle enough for daily use, it's suitable for all skin types, including sensitive and acne-prone skin, making it an easy layering step before serums or moisturizer.

C
CLCS28
Lovely consistency, great ingredients

All right, let's start with the price and get that out of the way - 78 dollars for 2 bottles (39 dollars a bottle) is not cheap. It's not drug store price, and also is definitely not the most expensive serum I have bought - not even close. To me the price is middle of the road. It's what you pay for a quality brand name that you trust, but not to the extend of products in the luxury space. These bottles are a good size, and a little goes a long way. So I see these bottles lasting long, if that's any consolation.I like the ingredient lineup, and they are great to add to a daily routine. I can't say whether this really delivers on all of the long terms claims - with so many products in my regular routine, who is to say what is doing what. Most of those fixes won't take place just by using serums but require intervention, so I know to set proper expectations. For how it is working for me daily, I like it. It's a pump bottle and pumps just the right amount. The consistency is like a thin lotion. It's not the liquid watery serum I am used to. It smooths on very well and easily and covers the face nicely. It does absorb well but I will say did leave a slight (VERY slight) feel of some sort on the surface after the fact. Not sticky, and not terrible, but felt the need to point out. Like if I put it on one side of my face and not the other, I would be able to feel a different on the surface of those sides. I am acne prone but haven't had any breakouts or adverse reactions with it.If it delivers on its claims, it's well worth the price. It's hard to pay that without knowing for sure. I do think the PDRN and peptides warrant a bit of a higher price than a standard serum, from what I have seen similarly on the market. I like it in a daily routine and think it's a great night time add. I do also appreciate that the box (not the bottle - so look at the box before throwing it away) lists where in your routine/product lineup it should be used! Not every serum will do that.

P
PremiumArt
Very nice/ not a fan of the scent.

Received this Gloves In a Bottle Pdrn serum and the only reason I took one star off is due to scent. Other that, it's a pretty nice serum.This PDRN serum has a creamy lightweight consistency that absorbs rapidly into the skin and leaves it soft and moisturized. It pairs well with my face cream too. Its non irritating and has some great ingredients.I'm not a fan of scented skincare and i could really smell grape. Perhaps it's the grape seed oil. It does vanish afterwards though.

G
Greeny
Great acne serum works well

Really great acne serum! I was a little doubtful on whether this would actually do anything but my skin cleared up within a couple of days of use! It surprised me because I think a lot of skincare serums don’t do much, but this one is very much worth it. The bottle is also bigger than I was expecting so while it is expensive, you get more of the product than with a lot of other serums. The ingredients are top notch and this brand is a good one. If you’re looking for a product that will actually clear your acne without damaging your skin, this is the one

A
Amazon Customer
Surprisingly gentle on my sensitive soft skin.

This is amazing! Love that it's on a two pack. Double there effectiveness. I have been using this daily and was a little bummed out that nothing was coming out after a while. I opened the top and saw that this does need to be turned upside down to pump out the serum.The serum is not thick or even overly runny. It does have a good balanced viscosity to be able to pump out a few drops on my finger tip and not have to drip off and get waisted. Wonderful blend of ingredients that are mild and do not irritate my skin as sadly many serums and ointments do for me. This absorbs well and quickly. No residue or off putting fragrance that lingers on me. My nose can be very sensitive.

A
A
Moisturizer with powerful ingredients

This serum has a great list of ingredients including Hyaluronic Acid, peptides, Niacinamide and Salmon DNA Complex so its great for moisturizing and repair. It has a convenient pump so isn’t messy. It is lightweight, non-greasy and absorbs quickly. The scent at first reminds me of a tasty pineapple dessert that I ate as a child, but then it becomes a little weird and I can’t name it. It has a plumping effect, and my skin looks brighter and healthier. This stuff isn’t cheap!

K
Kelly
Great for repairing the skin barrier

I bought this serum to help my teens with redness and irritation from their acne routines, and it’s been a game‑changer. Both of them use oil‑free cleansers and prescription acne medication, which can be really drying. After adding this serum right after cleansing, I’ve seen a visible improvement in their overall complexion -- less redness, calmer skin, and fewer dry patches.They both have acne‑prone skin, and this has genuinely helped repair their skin barrier and reduce irritation from their treatments. The texture is a little tacky at first, but they got used to it quickly and don’t mind it at all. If you’re dealing with dryness, irritation, or redness from acne products, this is absolutely worth trying.

B
Bob
Great on my skin!

This serum taps into salmon DNA (PDRN), an ingredient that supports skin repair and collagen production at a cellular level. Studies show it improves elasticity and boosts natural hyaluronic acid, so it's more than just hype. Niacinamide brightens and refines pores, while peptides help smooth fine lines over time. The lightweight texture absorbs quickly and layers well under other products. Getting a 2-pack makes sense since results build with consistent daily use. Gentle enough for sensitive skin, too.

A
A
Convenient spray-on toner

This lightweight toner/moisturizer is sprayed on, so it is very easy and quick to apply – even as a convenient top-up when you feel the need for some moisture. Try to avoid the eyes (as it stings). It has a crisp citrus scent. It makes your skin glisten while it dries, which is pretty quick. Sometimes I also rub it in. It is quickly absorbed. It makes my skin feel more plumped up. I like that it includes great ingredients for both moisturizing (hyaluronic acid and ceramides) and repair (peptides). My skin looks brighter. Reasonable price

V
Victoria
Hydrating with a pleasant scent

I got this because I'm always looking to improve my skincare routine and I haven't experimented with toners very much yet. As far as it's effectiveness as a toner I feel like the results are there but just a bit subtle for me. Definitely no negative effects like breakouts or dryness and its not heavy, sticky or greasy. The bottle is sturdy and attractive enough to be on display or make for a quality gift. It is hydrating and I think it's a nice addition to my skincare though perhaps not terribly necessary. It is a very refreshing face mist though and also has a nice grapefruit smell to it that I like. The atomizer sprays a pretty fine mist fairly evenly and the formula absorbs fairly quick. It's great for when I wash my face and end up getting distracted, then I spritz some of this and don't have to worry about putting my serum on super dry flaky skin. It has classic "skin loving" ingredients and even using a good amount every day it's lasting really well so far. It is on the higher end of my price range and since I'm not finding it absolutely essential it's something I probably won't repurchase but only because I'm on a pretty tight budget. Overall I think it's a really nice product and a soothing way to rehydrate the skin on these hot, dry days. Would recommend for anyone who dries out easily throughout the day.

T
Tara
Great for moisturizing and skin barrier

This spray toner has been a game changer for keeping my skin hydrated in this killer summer heat. I use it before my skincare and after when I feel like my face can use some extra hydration. The soothing and hydrating ingredients like the hyaluronic acid and the ceramides help nourish and protect your skin barrier so that you can have glowy and plump skin. The peptides in the toner might help but that will take a while to see results but as of now they seem to work well with the other ingredients in giving me soft skin.

A
Amy
Lightweight Toner That Absorbs Quickly

I've been really happy with this hydrating toner. It leaves my face feeling smooth, refreshed, and well hydrated without feeling sticky or heavy afterward. One of my favorite things about it is the sprayer. It produces a very fine, even mist that covers my entire face with just a couple of pumps. Because the mist is so fine, it absorbs into my skin quickly instead of leaving large droplets that need to be rubbed in. It doesn't feel sticky at all. It also layers nicely. It works well under serum, moisturizer, or makeup. The bottle contains 3.4 ounces, which is a nice size, so it should last a while. The pump feels well-made. This is a good value for the cost.

R
RC
Spray toner

The instructions say to close your eyes and spray this toner 4 to 8 inches away from your face. I tried that, but felt like I had to hold my breath because I didn't want to breathe it in. Also, as a mist spray, I felt that some of the product wasn't ending up on my face but in my hair and clothing. I would have preferred a spritz, but that's just my preference. Otherwise, the toner felt very lightweight and hydrating. It was absorbed into my skin quickly, probably because of the very thin layer. My face felt fresh, like just afte a shower.

B
Brian & Kelly Wittenmyer
Good serum with a fragrance

I’ve been pleasantly surprised by how well this Age Lift Serum performs. It has a lightweight texture that absorbs quickly without leaving behind a greasy or sticky feeling, making it easy to use both morning and night. My skin feels soft and hydrated after applying it.I feel like it has helped my skin feel tighter and smoothed some fine lines.The only downside for me is the scent. It has an unusual smell that I don’t particularly enjoy, and it takes away from the overall experience of using the product. Thankfully, the odor doesn’t linger for very long, and the serum itself works well enough that I still plan to use it. If fragrance doesn’t bother you, it’s a nice lightweight serum with a comfortable feel on the skin.

B
Bob
Balanced face serum!

This serum takes a balanced approach to acne-prone skin, focusing on calming and hydrating rather than harsh, stripping treatments that can leave skin irritated. Hyaluronic acid delivers lightweight hydration without clogging pores, while peptides support the skin's overall texture and resilience over time. The formula is designed to refine pores and smooth texture, making it a gentle option for skin that's reactive to typical acne treatments. Being non-comedogenic and lightweight, it absorbs quickly and layers well under moisturizer or sunscreen without feeling heavy or greasy.